Soviets put on impressive show

On working with the soviets.

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An impressive ceiling.

When Small Effects Are Impressive

Effect size is becoming an increasingly popular measure of the importance of an effect, both in individual studies and in meta-analyses. However, a large effect size is not the only way to demonstrate that an effect is important. This article describes 2 alternative methodological strategies, in which importance is a function of how minimal a manipulation of the independent variable or how diff...

Put your chips on transcriptomics.

The course of any disease is determined by a complex interplay between innate characteristics and environmental triggers. Accordingly, evidence-based risk factor assessment in heart disease requires a detailed family history to gauge inherited features and accurate estimates of smoking, diet, exercise, and other aspects that constitute important extrinsic disease modifiers. The value of traditi...

Cdks put Treslin on TopBP1

K umagai et al. describe how cy-clin-dependent kinases (Cdks) initiate DNA replication by promoting the interaction of two proteins conserved from yeast to mammals. In budding yeast, Cdks phosphorylate two replication origin proteins called Sld2 and Sld3, allowing them to bind a third protein called Dpb11. Together, these proteins recruit Cdc45, which then promotes the activation of the MCM hel...